The human blood coagulation system comprises a series of linked glycoproteins that upon activation induce the generation of downstream enzymes ultimately forming fibrin. This process is primarily important to arrest bleeding (hemostasis). Hemostasis is a typical example of a molecular machine, where the assembly of substrates, enzymes, protein cofactors and calcium ions on a phospholipid surface markedly accelerates the rate of coagulation. Excess, pathological, coagulation activity occurs in “thrombosis”, the formation of an intravascular clot, which in the most dramatic form (...) precipitates in the microvasculature as disseminated intravascular coagulation. Thrombosis occurs according to a biochemical machine model in the case of atherothrombosis on a ruptured atherosclerotic plaque, but may develop at a slower rate in venous thrombosis, illustrating that the coagulation machinery can act at different velocities. The separate coagulation enzymes are also important in other biological processes, including inflammation for which the rapid conversion of one coagulation factor by the other is not a prerequisite. The latter role of coagulation enzymes may be related to the old and probably maintained function of the coagulation machine in innate immunity. BioEssays 25:1220–1228, 2003. © 2003 Wiley Perioicals, Inc. (shrink)

Contents: Foreword. Wolfgang BALZER and C. ULISES MOULINES: Introduction. José A. DÍEZ CALZADA: Structuralist Analysis of Theories of Fundamental Measurement. Adolfo GARCÍA DE LA SIENRA and Pedro REYES: The Theory of Finite Games in Extensive Form. Hans Joachim BURSCHEID und Horst STRUVE: The Theory of Stochastic Fairness - its Historical Development, Formulation and Justification. Wolfgang BALZER and Richard MATTESSICH: Formalizing the Basis of Accounting. Werner DIEDERICH: A Reconstruction of Marxian Economics. Bert HAMMINGA and Wolfgang BALZER: The Basic Structure of (...) Neoclassical General Equilibrium Theory. Klaus MANHART: Balance Theories: Two Reconstructions and the Problem of Intended Applications. Rainer WESTERMANN: Festinger's Theory of Cognitive Dissonance: A Structuralist Theory-Net. Rainer REISENZEIN: Wundt's Three-Dimensional Theory of Emotion. Pablo LORENZANO: Classical Genetics and the Theory-Net of Genetics. Hinne HETTEMA and Theo A.F. KUIPERS: The Formalisation of the Periodic Table. C. ULISES MOULINES: The Basic Core of Simple Equilibrium Thermodynamics. Thomas BARTELBORTH: An Axiomatization of Classical Electrodynamics. Author's Index. Subject Index. (shrink)

Patient-reported outcomes are frequently used for medical decision making, at the levels of both individual patient care and healthcare policy. Evidence increasingly shows that PROs may be influenced by patients’ response shifts and dispositions. We identify how response shifts and dispositions may influence medical decisions on both the levels of individual patient care and health policy. We provide examples of these influences and analyse the consequences from the perspectives of ethical principles and theories of just distribution. If influences of response (...) shift and disposition on PROs and consequently medical decision making are not considered, patients may not receive optimal treatment and health insurance packages may include treatments that are not the most effective or cost-effective. We call on healthcare practitioners, researchers, policy makers, health insurers, and other stakeholders to critically reflect on why and how such patient reports are used. (shrink)

In this paper we analyze some aspects of the question of using methods from model theory to study structures of functional analysis.By a well known result of P. Lindström, one cannot extend the expressive power of first order logic and yet preserve its most outstanding model theoretic characteristics (e.g., compactness and the Löwenheim-Skolem theorem). However, one may consider extending the scope of first order in a different sense, specifically, by expanding the class of structures that are regarded as models (e.g., (...) including Banach algebras or other structures of functional analysis), and ask whether the resulting extensions of first order model theory preserve some of its desirable characteristics.A formal framework for the study of structures based on Banach spaces from the perspective of model theory was first introduced by C. W. Henson in [8] and [6]. Notions of syntax and semantics for these structures were defined, and it was shown that using them one obtains a model theoretic apparatus that satisfies many of the fundamental properties of first order model theory. For instance, one has compactness, Löwenheim-Skolem, and omitting types theorems. Further aspects of the theory, namely, the fundamentals of stability and forking, were first introduced in [10] and [9].The classes of mathematical structures formally encompassed by this framework are normed linear spaces, possibly expanded with additional structure,e.g., operations, real-valued relations, and constants. This notion subsumes wide classes of structures from functional analysis. However, the restriction that the universe of a structure be a normed space is not necessary. (This restriction has a historical, rather than technical origin; specifically, the development of the theory was originally motivated by questions in Banach space geometry.) Analogous techniques can be applied if the universe is a metric space. Now, when the underlying metric topology is discrete, the resulting model theory coincides with first order model theory, so this logic extends first order in the sense described above. Furthermore, without any cost in the mathematical complexity, one can also work in multi-sorted contexts, so, for instance, one sort could be an operator algebra while another is. say, a metric space. (shrink)

Paul de Man ha interpretado la teoría de la traducción de Walter Benjamín como precursora de las posiciones de la deconstrucción. Por el contrario, aquí se va a demostrar la centralidad del mesianismo en la teoría del lenguaje y de la traducción de Benjamín, así como en su posterior concepción materialista de la historia. Se va a mantener que la fuerza teórica del pensamiento de este autor tiene como base precisamente tal elemento teológico.

The text serves as an education program handbook for understanding the complexities of student engagement and providing access, equity, and justice for learners, with an emphasis on students with diverse backgrounds. The book examines current research and best practices on engagement for these learners and explores educational issues through social, cultural, and racial lenses.

Heidegger affirmed traditional technology, but was opposed to science-based modern technology, in which everything (including man) is considered to be a mere “resource”. This opposition was expressed in the form of deep questioning and a suspicion of superficial evaluation, because the true nature of things was often concealed, though disclosed at times. Ways in which engineers should question technology are proposed, highlighting some of the hazards and injustices associated with technology and also its subtle sociological and psychological influences. The demands (...) of engineering ethics and the use of metaphor in design are other ways in which a narrowly rationalistic technological outlook can be confronted. (shrink)

Neuroscience of art might give us traction with aesthetic issues. However it can be seen to have trouble modeling the artistically salient semantic properties of artworks. So if meaning really matters, and it does, even in aesthetic contexts, the prospects for this nascent field are dim. The issue boils down to a question of whether or not we can get a grip on the kinds of constraints present and available to guide interpretive behavior in our engagement with works of fine (...) art. I argue that biased competition models of selective attention can be used to solve this problem, generalize to the affective content of our responses to artworks, and so show that research in cognitive neuroscience is germane to the types of problems of interest within the philosophy of art. (shrink)

There are a growing number of publications arguing that if we had more wonder in social life, then its quality would be significantly improved, and that we therefore need an “ethics” or a “politics” of wonder. The aim of this paper is to show that that message is unfortunate, and this is for two reasons. First, wonder does not generally have the positive political and moral effects that are attributed to it, so to assume that it does may lead one (...) to adopt unrealistic social policies. Second, wonder does potentially have a number of negative moral and politicaleffects, so social policies that put a premium on wonder may bring adverse consequences. In this way, the paper makes a general case against wonder as a positive force in morality and politics. (shrink)

This paper describes how some aspects of Martin Heidegger’s philosophy resonate strongly with an engineering outlook. He argued that practice was more “primordial” than theory, though preserving an important role for theoretical understanding as well, thus speaking to the gap between engineering education (highly theoretical) and engineering practice (mostly empirical). He also underlined the reality of “average” practices into which we are socialized, though affirming the potential for original work and action too, thus providing the grounds for self-actualization whether within (...) the routine or in transcending it. His notion of “thrownness” emphasizes the importance of context, with which engineers are constantly engaged. While all this relates to the idea of our “being”, Heidegger also dealt with the influence of time on our practices. Future death could be seen as spurring innovation, cultural history as a source for critiquing current practice and the present “situation” as the immediate context for corrective action. His major book is appropriately called “Being and Time”.1. (shrink)